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Article

Valproic acid activates notch-1 signaling and regulates the neuroendocrine phenotype in carcinoid cancer cells.

The oncologist - 1 Aug 2007

Greenblatt David Yu, Vaccaro Abram M, Jaskula-Sztul Renata, Ning Li, Haymart Megan, Kunnimalaiyaan Muthusamy, Chen Herbert

Abstract excerpt

Carcinoid tumors are neuroendocrine malignancies that frequently metastasize and secrete hormones that cause debilitating symptoms in patients. In this study we report the effects of valproic acid (VPA), a drug long used for the treatment of epilepsy, on the growth and neuroendocrine phenotype of human carcinoid cancer cells. VPA treatment of gastrointestinal and pulmonary carcinoid cells resulted in a...

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Identifiers

PMID: 17766653
DOI: 10.1634/theoncologist.12-8-942

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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