Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohort.

International journal of obesity (2005) - 1 Jan 2017

Vollbach H, Brandt S, Lahr G, Denzer C, von Schnurbein J, Debatin K-M, Wabitsch M

Abstract excerpt

OBJECTIVE: We aimed to determine the prevalence of melanocortin-4 receptor (MC4R) variants in a large German cohort of children with obesity in a pediatric outpatient clinic and to ascertain whether there is a specific phenotype associated with loss-of-function variants as previously reported. STUDY DESIGN: Eight hundred and ninety-nine patients from our pediatric obesity clinic were screened for MC4R variants by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Germany
Share to Infant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Infant, Newborn

Share to Loss of Function Mutation

Share to Pediatric Obesity

Share to Prevalence

Share to Receptor, Melanocortin, Type 4

Source

Identifiers

PMID: 27654141
DOI: 10.1038/ijo.2016.161

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prevalence and phenotypic characterization of MC4R variants in a large pediatric cohort.PMID 27654141Read ↗

Clinical and functional relevance of melanocortin-4 receptor variants in obese German children.Semantic proximity Read ↗

Melanocortin-4 receptor gene mutations in a Dutch cohort of obese children.Semantic proximity Read ↗

Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis.Semantic proximity Read ↗

Characterization of Rare Variants in MC4R in African American and Latino Children With Severe Early-Onset Obesity.Semantic proximity Read ↗

[Prevalence of melanocortin 4 receptor (MC4R) mutations and polymorphismsin consecutively ascertained obese children and adolescents from a pediatric health care utilization population].Semantic proximity Read ↗

Clinical and Functional Characterization of Melanocortin 4 Receptor genetic variants in African American and/or Hispanic children with severe early onset obesity.Semantic proximity Read ↗

Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort.Semantic proximity Read ↗

Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene.Semantic proximity Read ↗

A novel mutation Thr162Arg of the melanocortin 4 receptor gene in a Spanish children and adolescent population.Semantic proximity Read ↗

Melanocortin 4 receptor (MC4R) gene variants in children and adolescents having familial early-onset obesity: genetic and clinical characteristics.Semantic proximity Read ↗

Melanocortin-4 receptor gene mutations in obese Slovak children.Semantic proximity Read ↗

Identification and functional characterization of novel mutations in the melanocortin-4 receptor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.