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Article

Loss of imprinting and allelic switching at the DLK1-MEG3 locus in human hepatocellular carcinoma.

PloS one - 1 Jan 2012

Anwar Sumadi Lukman, Krech Till, Hasemeier Britta, Schipper Elisa, Schweitzer Nora, Vogel Arndt, Kreipe Hans, Lehmann Ulrich

Abstract excerpt

Deregulation of imprinted genes is an important molecular mechanism contributing to the development of cancer in humans. However, knowledge about imprinting defects in human hepatocellular carcinoma (HCC), the third leading cause of cancer mortality worldwide, is still limited. Therefore, a systematic meta-analysis of the expression of 223 imprinted loci in human HCC was initiated. This screen revealed that the...

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Topics

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Share to Calcium-Binding Proteins
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Gene Expression Regulation, Neoplastic

Share to Genomic Imprinting

Share to Intercellular Signaling Peptides and Proteins

Share to Liver Neoplasms

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 23145177
DOI: 10.1371/journal.pone.0049462
PMCID: PMC3493531

Genes

DLK1
DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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