Article
The Lon protease is essential for full virulence in Pseudomonas aeruginosa.
PloS one - 1 Jan 2012
Breidenstein Elena B M, Janot Laure, Strehmel Janine, Fernandez Lucia, Taylor Patrick K, Kukavica-Ibrulj Irena, Gellatly Shaan L, Levesque Roger C, Overhage Joerg, Hancock Robert E W
Abstract excerpt
Pseudomonas aeruginosa PAO1 lon mutants are supersusceptible to ciprofloxacin, and exhibit a defect in cell division and in virulence-related properties, such as swarming, twitching and biofilm formation, despite the fact that the Lon protease is not a traditional regulator. Here we set out to investigate the influence of a lon mutation in a series of infection models. It was demonstrated that the lon mutant had...
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