Article

Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation in <i>Pseudomonas aeruginosa</i>

2025-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Proteases regulate important biological functions. Here we present the structural and functional characterization of three previously uncharacterized aspartic proteases in Pseudomonas aeruginosa . We show that these proteases have structural hallmarks of retropepsin peptidases and play redundant roles for cell survival under hypoosmotic stress conditions. Consequently, we named them retropepsin...

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Literature Corpus work: a1a08f59-3ca1-5904-b1ed-431c9b67731c
DOI: 10.1101/2025.03.18.643919

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