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Article

Quorum sensing-dependent post-secretional activation of extracellular proteases in Pseudomonas aeruginosa.

The Journal of biological chemistry - 20 Dec 2019

Li Xi-Hui, Lee Joon-Hee

Abstract excerpt

Pseudomonas aeruginosa secretes multiple proteases that are implicated in its pathogenesis, and most of them are regulated by quorum sensing (QS). In this study, we found that the activities of three major extracellular proteases, protease IV (PIV), elastase A (LasA), and elastase B (LasB), are reduced considerably when expressed in a QS mutant (MW1). PIV and LasA expressed in MW1 exhibited little activity, even...

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Identifiers

PMID: 31727738
DOI: 10.1074/jbc.RA119.011047
PMCID: PMC6926461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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