Article
Impaired spermatogenesis and male fertility defects in CIZ/Nmp4-disrupted mice.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2004
Nakamoto Tetsuya, Shiratsuchi Akiko, Oda Hideaki, Inoue Keiichi, Matsumura Tomoko, Ichikawa Motoshi, Saito Toshiki, Seo Sachiko, Maki Kazuhiro, Asai Takashi, Suzuki Takahiro, Hangaishi Akira, Yamagata Tetsuya, Aizawa Shinichi, Noda Masaki, Nakanishi Yoshinobu, Hirai Hisamaru
Abstract excerpt
CIZ (Cas interacting zinc finger protein), also called Nmp4 (nuclear matrix protein 4), is a nucleo-cytoplasmic shuttling transcription factor that regulates the expression of collagen and matrix metalloproteinases. CIZ/Nmp4 was originally cloned by its binding to p130(Cas), a focal adhesion protein, and was recently shown to suppress BMP2 (bone mophogenetic protein 2) signalling. To explore the physiological...
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