Article

MACF1 Facilitates SMAD7 Nuclear Translocation to Drive Bone Formation in Mice

2019-08-25

Abstract excerpt

<h4>ABSTRACT</h4> MACF1 is a large crosslinker that contributes to cytoskeleton integrity and cell differentiation. Loss of MACF1 impairs multiple cellular functions in neuron development and epidermal migration, and is the molecular basis for many diseases such as heart failure and Parkinson’s disease. MACF1 is highly abundant in bones, however, its involvements in osteogenic differentiation and bone formation a...

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Literature Corpus work: 674df588-6c46-5f76-b2a1-3f549ca02a42
DOI: 10.1101/743930

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