Article
Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2001
Thunyakitpisal P, Alvarez M, Tokunaga K, Onyia J E, Hock J, Ohashi N, Feister H, Rhodes S J, Bidwell J P
Abstract excerpt
Collagen expression is coupled to cell structure in connective tissue. We propose that nuclear matrix architectural transcription factors link cell shape with collagen promoter geometry and activity. We previously indicated that nuclear matrix proteins (NP/NMP4) interact with the rat type I collagen alpha1(I) polypeptide chain (COL1A1) promoter at two poly(dT) sequences (sites A and B) and bend the DNA. Here, our...
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