Article
Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C.
World journal of gastroenterology - 7 Nov 2012
Tsubota Akihito, Shimada Noritomo, Abe Hiroshi, Yoshizawa Kai, Agata Rie, Yumoto Yoko, Ika Makiko, Namiki Yoshihisa, Nagatsuma Keisuke, Matsudaira Hiroshi, Fujise Kiyotaka, Tada Norio, Aizawa Yoshio
Abstract excerpt
AIM: To construct formulae for predicting the likelihood of ribavirin-induced anemia in pegylated interferon α plus ribavirin for chronic hepatitis C. METHODS: Five hundred and sixty-one Japanese patients with hepatitis C virus genotype 1b who had received combination treatment were enrolled and assigned randomly to the derivation and confirmatory groups. Single nucleotide polymorphisms at or nearby ITPA were...
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