Article
Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C.
Journal of medical virology - 1 Mar 2013
Kurosaki Masayuki, Tanaka Yasuhito, Nishida Nao, Sakamoto Naoya, Enomoto Nobuyuki, Matsuura Kentaro, Asahina Yasuhiro, Nakagawa Mina, Watanabe Mamoru, Sakamoto Minoru, Maekawa Shinya, Tokunaga Katsushi, Mizokami Masashi, Izumi Namiki
Abstract excerpt
This study aimed to develop a model for predicting anemia using the inosine triphosphatase (ITPA) genotype and to evaluate its relationship with treatment outcome. Patients with genotype 1b chronic hepatitis C (n = 446) treated with peg-interferon alpha and ribavirin (RBV) for 48 weeks were genotyped for the ITPA (rs1127354) and IL28B (rs8099917) genes. Data mining analysis generated a predictive model for anemia...
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