Article
ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.
Gastroenterology - 1 Oct 2010
Ochi Hidenori, Maekawa Toshiro, Abe Hiromi, Hayashida Yasufumi, Nakano Rikita, Kubo Michaki, Tsunoda Tatsuhiko, Hayes C Nelson, Kumada Hiromitsu, Nakamura Yusuke, Chayama Kazuaki
Abstract excerpt
BACKGROUND & AIMS: Ribavirin-induced anemia is one of the major causes of discontinuation and dose reduction during anti-hepatitis C virus therapy. Factors influencing this anemia, especially host genetic factors, are poorly understood. In this study we investigated predictive factors in hepatitis C virus patients treated with combination therapy. METHODS: We performed a 2-step genome-wide screening followed by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.