Article
Association of ITPA gene polymorphisms and the risk of ribavirin-induced anemia in HIV/hepatitis C virus (HCV)-coinfected patients receiving HCV combination therapy.
Antimicrobial agents and chemotherapy - 1 Jun 2012
Domingo Pere, Guardiola Josep M, Salazar Juliana, Torres Ferran, Mateo M Gracia, Pacho Cristina, Del Mar Gutierrez M, Lamarca Karuna, Fontanet Angels, Martin Jordi, Muñoz Jessica, Vidal Francesc, Baiget Montserrat
Abstract excerpt
Polymorphisms of the ITPA gene have been associated with anemia during combination therapy in hepatitis C virus (HCV)-monoinfected patients. Our aim was to confirm this association in HIV/HCV-coinfected patients. In this prospective, observational study, 73 HIV/HCV-coinfected patients treated with pegylated interferon plus ribavirin (RBV) were enrolled. Two single nucleotide polymorphisms within or adjacent to...
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