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Article

Insights into the molecular mechanism for type 2 diabetes susceptibility at the KCNQ1 locus from temporal changes in imprinting status in human islets.

Diabetes - 1 Mar 2013

Travers Mary E, Mackay Deborah J G, Dekker Nitert Marloes, Morris Andrew P, Lindgren Cecilia M, Berry Andrew, Johnson Paul R, Hanley Neil, Groop Leif C, McCarthy Mark I, Gloyn Anna L

Abstract excerpt

The molecular basis of type 2 diabetes predisposition at most established susceptibility loci remains poorly understood. KCNQ1 maps within the 11p15.5 imprinted domain, a region with an established role in congenital growth phenotypes. Variants intronic to KCNQ1 influence diabetes susceptibility when maternally inherited. By use of quantitative PCR and pyrosequencing of human adult islet and fetal pancreas...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23139357
DOI: 10.2337/db12-0819
PMCID: PMC3581222

Genes

KCNQ1
PHLDA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Insights into the molecular mechanism for type 2 diabetes susceptibility at the KCNQ1 locus from temporal changes in imprinting status in human islets.PMID 23139357Read ↗

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