Article
Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.
Circulation research - 27 May 2005
Yang Xudong, Long Lu, Southwood Mark, Rudarakanchana Nung, Upton Paul D, Jeffery Trina K, Atkinson Carl, Chen Hailan, Trembath Richard C, Morrell Nicholas W
Abstract excerpt
Mutations in the bone morphogenetic protein type II receptor gene (BMPR2) are the major genetic cause of familial pulmonary arterial hypertension (FPAH). Although smooth muscle cell proliferation contributes to the vascular remodeling observed in PAH, the role of BMPs in this process and the impact of BMPR2 mutation remains unclear. Studies involving normal human pulmonary artery smooth muscle cells (PASMCs)...
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