The BMP Receptor 2 in Pulmonary Arterial Hypertension: When and Where the Animal Model Matches the Patient

Abstract excerpt

Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the development of hereditary pulmonary arterial hypertension (PAH). In non-hereditary forms of PAH, perturbations in the transforming growth factor-β (TGF-β)/BMP-axis are believed to cause deficient BMPR2 signaling by changes in receptor expression, the activity of the receptor and/or downstream signaling. To date, BMPR2...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Share to Medical Imaging and Pathology Studies
• Share to Pulmonary Hypertension Research and Treatments