Article
Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.
Circulation research - 23 Jul 2010
Yang Jun, Li Xiaohui, Al-Lamki Rafia S, Southwood Mark, Zhao Jing, Lever Andrew M, Grimminger Friedrich, Schermuly Ralph T, Morrell Nicholas W
Abstract excerpt
RATIONALE: Mutations in the bone morphogenetic protein type II receptor (BMPR-II) are responsible for the majority of cases of heritable pulmonary arterial hypertension (PAH). Mutations lead to reduced Smad1/5-driven expression of inhibitor of DNA binding protein 1 (Id1) and loss of the growth su...
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