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Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells

15 Jun 2013

Abstract excerpt

Bone morphogenetic protein type II receptor (BMPR-II) mutations are responsible for over 70% of cases of heritable pulmonary arterial hypertension (PAH). Loss of BMP signaling promotes pulmonary vascular remodeling via modulation of pulmonary artery smooth muscle cell (PASMC) proliferation. Id proteins (Id1-4) are major downstream transcriptional targets of BMP signaling. However, the impact of BMPR-II mutation...

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Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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PMID: 23771884
DOI: 10.1152/ajplung.00054.2013

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