Article
Analysis of recombinants in female mouse meiosis.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2013
de Boer Esther, Jasin Maria, Keeney Scott
Abstract excerpt
During meiosis, homologous chromosomes (homologs) undergo recombinational interactions, resulting in the formation of crossovers (COs) or noncrossovers (NCOs). Both COs and NCOs are initiated by the same event: programmed double-strand DNA breaks (DSBs), which occur preferentially at hotspots throughout the genome. COs contribute to the genetic diversity of gametes and are needed to promote proper meiotic...
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