Article
Association of IL28B gene variations with mathematical modeling of viral kinetics in chronic hepatitis C patients with IFN plus ribavirin therapy.
Proceedings of the National Academy of Sciences of the United States of America - 1 Mar 2011
Hsu Ching-Sheng, Hsu Shih-Jer, Chen Hung-Chia, Tseng Tai-Chung, Liu Chen-Hua, Niu Wei-Fang, Jeng Jenher, Liu Chun-Jen, Lai Ming-Yang, Chen Pei-Jer, Kao Jia-Horng, Chen Ding-Shinn
Abstract excerpt
Asian patients with chronic hepatitis C (CHC) are known to have better virological responses to pegylated (Peg) IFN-based therapy than Western patients. Although IL28B gene polymorphisms may contribute to this difference, whether favorable hepatitis C virus (HCV) kinetics during treatment plays a role remains unclear. We enrolled 145 consecutive Taiwanese patients with CHC receiving Peg-IFN α-2a plus ribavirin...
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