Article
Mucosal tissue tropism and dissemination of HIV-1 subtype B acute envelope-expressing chimeric virus.
Journal of virology - 1 Jan 2013
King Deborah F L, Siddiqui Asna A, Buffa Viviana, Fischetti Lucia, Gao Yong, Stieh Daniel, McKay Paul F, Rogers Paul, Ochsenbauer Christina, Kappes John C, Arts Eric J, Shattock Robin J
Abstract excerpt
Human immunodeficiency virus type 1 (HIV-1) transmission results from infection with one or a small number of variants from the donor quasispecies. Transmitted/founder (T/F) viruses have recently been identified from acutely infected patients, but the way in which they interact with primary targets of HIV-1 infection is poorly understood. We have conducted a biological characterization of a panel of subtype B T/F...
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