Article
Dendritic cell-mediated HIV-1 infection of T cells demonstrates a direct relationship to plasma viral RNA levels.
Journal of acquired immune deficiency syndromes (1999) - 1 Jun 2010
Arora Reetakshi, Bull Lara, Siwak Edward B, Thippeshappa Rajesh, Arduino Roberto C, Kimata Jason T
Abstract excerpt
OBJECTIVE: To examine the relationship between infectivity of HIV-1 variants in dendritic cell (DC)-mediated in trans infection of T cells and plasma viral RNA levels in infected subjects. METHODS: HIV-1 was isolated from peripheral blood mononuclear cells of chronically infected individuals, typed for coreceptor usage, and viral replication were examined in monocyte-derived DCs-peripheral blood lymphocytes...
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