Article
Transmitted/founder (T/F) HIV-1 derived from sexual contact exhibits greater transmission fitness in human cervical tissue than T/F HIV-1 from blood-to-blood contact: Unique glycan profiles on T/F envelopes associated with transmission phenotypes.
PLoS pathogens - 1 May 2025
Zhang Yiying, Klein Katja, Ratcliff Annette, Galappaththi Sashini Loku, Hathaway Nicholas, Twells Nicholas, Patel Mukti, Temesy Stephen, Bailey Jeffrey A, Mahal Lara K, Creuzenet Carole, Arts Eric J
Abstract excerpt
Human immunodeficiency virus 1 (HIV-1) risk groups include, but are not limited to, heterosexual individuals (HET), men-who-have-sex-with-men (MSM), and people who inject drugs (PWID). Although genetically diverse HIV-1 populations are transferred from donor to recipient, systemic infection is often established by a single clone, the transmitted/founder (T/F) virus. This phenomenon is especially prevalent in...
Read the complete abstract on PubMedTopics
- Humans
- HIV-1
- Female
- HIV Infections
- Polysaccharides