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Article

Transmission of highly virulent CXCR4 tropic HIV-1 through the mucosal route in an individual with a wild-type CCR5 genotype.

EBioMedicine - 1 Nov 2024

Marichannegowda Manukumar Honnayakanahalli, Setua Saini, Bose Meera, Sanders-Buell Eric, King David, Zemil Michelle, Wieczorek Lindsay, Diaz-Mendez Felisa, Chomont Nicolas, Thomas Rasmi, Francisco Leilani, Eller Leigh Anne, Polonis Victoria R, Tovanabutra Sodsai, Heredia Alonso, Tagaya Yutaka, Michael Nelson L, Robb Merlin L, Song Hongshuo

Abstract excerpt

BACKGROUND: Nearly all transmitted/founder (T/F) HIV-1 are CCR5 (R5)-tropic. While previous evidence suggested that CXCR4 (X4)-tropic HIV-1 are transmissible, virus detection and characterization were not at the earliest stages of acute infection. METHODS: We identified an X4-tropic T/F HIV-1 in a participant (40700) in the RV217 acute infection cohort. Coreceptor usage was determined in TZM-bl cell line,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39427414
DOI: 10.1016/j.ebiom.2024.105410
PMCID: PMC11533037

Genes

CD4
CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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