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Article

Design of meningococcal factor H binding protein mutant vaccines that do not bind human complement factor H.

Infection and immunity - 1 Aug 2012

Pajon Rolando, Beernink Peter T, Granoff Dan M

Abstract excerpt

Meningococcal factor H binding protein (fHbp) is a human species-specific ligand for the complement regulator, factor H (fH). In recent studies, fHbp vaccines in which arginine at position 41 was replaced by serine (R41S) had impaired fH binding. The mutant vaccines elicited bactericidal responses in human fH transgenic mice superior to those elicited by control fHbp vaccines that bound human fH. Based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22615247
DOI: 10.1128/IAI.00103-12
PMCID: PMC3434564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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