Article
Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1.
PloS one - 1 Jan 2017
Marini Arianna, Rossi Omar, Aruta Maria Grazia, Micoli Francesca, Rondini Simona, Guadagnuolo Serafina, Delany Isabel, Henderson Ian R, Cunningham Adam F, Saul Allan, MacLennan Calman A, Koeberling Oliver
Abstract excerpt
Factor H-binding protein (fHbp) is an important meningococcal vaccine antigen. Native outer membrane vesicles with over-expressed fHbp (NOMV OE fHbp) have been shown to induce antibodies with broader functional activity than recombinant fHbp (rfHbp). Improved understanding of this broad coverage would facilitate rational vaccine design. We performed a pair-wise analysis of 48 surface-exposed amino acids involved...
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