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Article

A Mutant Library Approach to Identify Improved Meningococcal Factor H Binding Protein Vaccine Antigens.

PloS one - 1 Jan 2015

Konar Monica, Rossi Raffaella, Walter Helen, Pajon Rolando, Beernink Peter T

Abstract excerpt

Factor H binding protein (FHbp) is a virulence factor used by meningococci to evade the host complement system. FHbp elicits bactericidal antibodies in humans and is part of two recently licensed vaccines. Using human complement Factor H (FH) transgenic mice, we previously showed that binding of FH decreased the protective antibody responses to FHbp vaccination. Therefore, in the present study we devised a...

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Share to Antibody Formation
Share to Antigens, Bacterial
Share to Calorimetry, Differential Scanning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Complement Factor H

Share to Meningococcal Vaccines

Share to Protein Stability

Share to Surface Plasmon Resonance

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Identifiers

PMID: 26057742
DOI: 10.1371/journal.pone.0128185
PMCID: PMC4461315

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