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Article

CaMK4 Gene Deletion Induces Hypertension

6 Aug 2012

Abstract excerpt

BACKGROUND: The expression of calcium/calmodulin-dependent kinase IV (CaMKIV) was hitherto thought to be confined to the nervous system. However, a recent genome-wide analysis indicated an association between hypertension and a single-nucleotide polymorphism (rs10491334) of the human CaMKIV gene (CaMK4), which suggests a role for this kinase in the regulation of vascular tone. METHODS AND RESULTS: To directly...

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PMID: 23130158
DOI: 10.1161/jaha.112.001081

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