Article
Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.
Rejuvenation research - 1 Jun 2011
Malovini Alberto, Illario Maddalena, Iaccarino Guido, Villa Francesco, Ferrario Anna, Roncarati Roberta, Anselmi Chiara Viviani, Novelli Valeria, Cipolletta Ersilia, Leggiero Eleonora, Orro Alessandro, Rusciano Maria Rosaria, Milanesi Luciano, Maione Angela Serena, Condorelli Gianluigi, Bellazzi Riccardo, Puca Annibale A
Abstract excerpt
Long-living individuals (LLIs) are used to study exceptional longevity. A number of genetic variants have been found associated in LLIs to date, but further identification of variants would improve knowledge on the mechanisms regulating the rate of aging. Therefore, we performed a genome-wide association study on 410 LLIs and 553 young control individuals with a 317K single-nucleotide polymorphism (SNP) chip to...
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