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Article

Group I and II mammalian PAKs have different modes of activation by Cdc42.

EMBO reports - 29 Jun 2012

Baskaran Yohendran, Ng Yuen-Wai, Selamat Widyawilis, Ling Felicia Tay Pei, Manser Ed

Abstract excerpt

p21-activated kinases (PAKs) are Cdc42 effectors found in metazoans, fungi and protozoa. They are subdivided into PAK1-like (group I) or PAK4-like (group II) kinases. Human PAK4 is widely expressed and its regulatory mechanism is unknown. We show that PAK4 is strongly inhibited by a newly identified auto-inhibitory domain (AID) formed by amino acids 20 to 68, which is evolutionarily related to that of other PAKs....

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Share to Enzyme Activation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22653441
DOI: 10.1038/embor.2012.75
PMCID: PMC3388789

Genes

PAK4
PAK1

Provenance

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