Article
PAK3 is a key signature gene of the glioma proneural subtype and affects its proliferation, differentiation and growth.
Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2021
Magne Nathalie, Rousseau Véronique, Duarte Kévin, Poëa-Guyon Sandrine, Gleize Vincent, Mutel Alexandre, Schmitt Charlotte, Castel Hélène, Idbaih Ahmed, Huillard Emmanuelle, Sanson Marc, Barnier Jean-Vianney
Abstract excerpt
PURPOSE: Gliomas are the most lethal adult primary brain cancers. Recent advances in their molecular characterization have contributed to a better understanding of their pathophysiology, but there is still a need to identify key genes controling glioma cell proliferation and differentiation. The p21-activated kinases PAK1 and PAK2 play essential roles in cell division and brain development and are well-known...
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