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Article

Transcriptional elongation factor elongin A regulates retinoic acid-induced gene expression during neuronal differentiation.

Cell reports - 29 Nov 2012

Yasukawa Takashi, Bhatt Shachi, Takeuchi Tamotsu, Kawauchi Junya, Takahashi Hidehisa, Tsutsui Aya, Muraoka Takuya, Inoue Makoto, Tsuda Masayuki, Kitajima Shigetaka, Conaway Ronald C, Conaway Joan W, Trainor Paul A, Aso Teijiro

Abstract excerpt

Elongin A increases the rate of RNA polymerase II (pol II) transcript elongation by suppressing transient pausing by the enzyme. Elongin A also acts as a component of a cullin-RING ligase that can target stalled pol II for ubiquitylation and proteasome-dependent degradation. It is not known whether these activities of Elongin A are functionally interdependent in vivo. Here, we demonstrate that Elongin A-deficient...

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Identifiers

PMID: 23122963
DOI: 10.1016/j.celrep.2012.09.031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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