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Article

ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.

The Journal of biological chemistry - 18 Feb 2005

Heuzé Mélina L, Guibal Florence C, Banks Charles A, Conaway Joan W, Conaway Ronald C, Cayre Yvon E, Benecke Arndt, Lutz Pierre G

Abstract excerpt

The ankyrin repeat-containing protein with a suppressor of cytokine signaling box-2 (ASB2) gene was identified as a retinoic acid-response gene and a target of the promyelocytic leukemia-retinoic acid receptor-alpha oncogenic protein characteristic of acute promyelocytic leukemia. Expression of ASB2 in myeloid leukemia cells inhibits growth and promotes commitment, recapitulating an early step known to be...

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Identifiers

PMID: 15590664
DOI: 10.1074/jbc.M413040200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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