Article
ASB2 is an Elongin BC-interacting protein that can assemble with Cullin 5 and Rbx1 to reconstitute an E3 ubiquitin ligase complex.
The Journal of biological chemistry - 18 Feb 2005
Heuzé Mélina L, Guibal Florence C, Banks Charles A, Conaway Joan W, Conaway Ronald C, Cayre Yvon E, Benecke Arndt, Lutz Pierre G
Abstract excerpt
The ankyrin repeat-containing protein with a suppressor of cytokine signaling box-2 (ASB2) gene was identified as a retinoic acid-response gene and a target of the promyelocytic leukemia-retinoic acid receptor-alpha oncogenic protein characteristic of acute promyelocytic leukemia. Expression of ASB2 in myeloid leukemia cells inhibits growth and promotes commitment, recapitulating an early step known to be...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Carrier Proteins
- Cell Line
- Cullin Proteins
- Elongin
- Humans
- Leukemia
- Multiprotein Complexes
- Mutation
- Proteasome Endopeptidase Complex
- Protein Binding
- Protein Processing, Post-Translational