Article

Developmental regulation of neuronal gene expression by Elongator complex protein 1 dosage

2021-04-16

Abstract excerpt

Elongator is a highly conserved protein complex required for transcriptional elongation, intracellular transport and translation. Elongator complex protein 1 (ELP1) is the scaffolding protein of Elongator and is essential for its assembly and stability. Familial dysautonomia (FD), a hereditary sensory and autonomic neuropathy, is caused by a mutation in ELP1 that lead to a tissue-specific reduction of ELP1 protei...

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Literature Corpus work: 8963ebd3-6a78-56fb-8e7f-34dac26ad011
DOI: 10.1101/2021.04.16.440179

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