Article
Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia.
Molecular cell - 19 May 2006
Close Pierre, Hawkes Nicola, Cornez Isabelle, Creppe Catherine, Lambert Charles A, Rogister Bernard, Siebenlist Ulrich, Merville Marie-Paule, Slaugenhaupt Susan A, Bours Vincent, Svejstrup Jesper Q, Chariot Alain
Abstract excerpt
Mutations in IKBKAP, encoding a subunit of Elongator, cause familial dysautonomia (FD), a severe neurodevelopmental disease with complex clinical characteristics. Elongator was previously linked not only with transcriptional elongation and histone acetylation but also with other cellular processes. Here, we used RNA interference (RNAi) and fibroblasts from FD patients to identify Elongator target genes and study...
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