Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biochemical and immunological mechanisms by which sickle cell trait protects against malaria

11 Sept 2013

Abstract excerpt

Sickle cell trait (HbAS) is the best-characterized genetic polymorphism known to protect against falciparum malaria. Although the protective effect of HbAS against malaria is well known, the mechanism(s) of protection remain unclear. A number of biochemical and immune-mediated mechanisms have been proposed, and it is likely that multiple complex mechanisms are responsible for the observed protection. Increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hemoglobinopathies and Related Disorders
Share to Malaria Research and Control
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24025776
DOI: 10.1186/1475-2875-12-317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biochemical and immunological mechanisms by which sickle cell trait protects against malariaPMID 24025776Read ↗

An Immune Basis for Malaria Protection by the Sickle Cell TraitSemantic proximity Read ↗

Protective effects of the sickle cell gene against malaria morbidity and mortality.Semantic proximity Read ↗

Sickle cell trait is associated with controlled levels of haem and mild proinflammatory response during acute malaria infection.Semantic proximity Read ↗

The triumph of good over evil: protection by the sickle gene against malaria.Semantic proximity Read ↗

Haemoglobinopathies and resistance to malaria.Semantic proximity Read ↗

Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria PathogenesisSemantic proximity Read ↗

Human genetic variations conferring resistance to malaria.Semantic proximity Read ↗

Human red blood cell polymorphisms prevalent in Colombian population and its protective role against malaria.Semantic proximity Read ↗

A Review of the Relationship between the Immune Response, Inflammation, Oxidative Stress, and the Pathogenesis of Sickle cell AnaemiaSemantic proximity Read ↗

Comparative haematological parameters of HbAA and HbAS genotype children infected with Plasmodium falciparum malaria in Yemen.Semantic proximity Read ↗

Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait.Semantic proximity Read ↗

Hemoglobin Genotypes Modulate Inflammatory Response to Plasmodium Infection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.