Article

Impact of sickle cell trait hemoglobin on the intraerythrocytic transcriptional program of <i>Plasmodium falciparum</i>

2021-08-09

Abstract excerpt

Sickle-trait hemoglobin (HbAS) confers near-complete protection from severe, life-threatening falciparum malaria in African children. Despite this clear protection, the molecular mechanisms by which HbAS confers these protective phenotypes remain incompletely understood. As a forward genetic screen for aberrant parasite transcriptional responses associated with parasite neutralization in HbAS red blood cells (RBCs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7c898608-9f57-5f22-be06-584e12e5bfba
DOI: 10.1101/2021.08.06.455439

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Impact of sickle cell trait hemoglobin on the intraerythrocytic transcriptional program of <i>Plasmodium falciparum</i>DOI 10.1101/2021.08.06.455439Read

Seasonal transcriptional profiling of malaria parasites using a new single-cell atlas of a Malian <i>Plasmodium falciparum</i> isolateSemantic proximity Read

Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytesSemantic proximity Read

Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria PathogenesisSemantic proximity Read

Latent transcriptional variations of individual Plasmodium falciparum uncovered by single-cell RNA-seq and fluorescence imagingSemantic proximity Read

A single-cell atlas of <i>Plasmodium falciparum</i> transmission through the mosquitoSemantic proximity Read

Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites.Semantic proximity Read

The Malaria Cell Atlas: a comprehensive reference of single parasite transcriptomes across the complete <i>Plasmodium</i> life cycleSemantic proximity Read

Malian children infected with <i>Plasmodium ovale</i> and <i>Plasmodium falciparum</i> display very similar gene expression profilesSemantic proximity Read

Integrative genomics of <i>Plasmodium knowlesi</i> reveals parasite-intrinsic regulators of severe human malariaSemantic proximity Read

Single-cell transcriptomics to define <i>Plasmodium falciparum</i> stage-transition in the mosquito midgutSemantic proximity Read

New insights into the blood‐stage transcriptome of <i>Plasmodium falciparum</i> using RNA‐SeqSemantic proximity Read

Transcriptome and histone epigenome of <i>Plasmodium vivax</i> salivary-gland sporozoites point to tight regulatory control and potential mechanisms for liver-stage differentiationSemantic proximity Read