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Article

Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels.

International journal of molecular sciences - 19 Apr 2023

Oxendine Harp Keri, Bashi Alaijah, Botchway Felix, Addo-Gyan Daniel, Tetteh-Tsifoanya Mark, Lamptey Amanda, Djameh Georgina, Iqbal Shareen A, Lekpor Cecilia, Banerjee Saswati, Wilson Michael D, Dei-Adomakoh Yvonne, Adjei Andrew A, Stiles Jonathan K, Driss Adel

Abstract excerpt

Malaria affects a significant portion of the global population, with 247 million cases in 2021, primarily in Africa. However, certain hemoglobinopathies, such as sickle cell trait (SCT), have been linked to lower mortality rates in malaria patients. Hemoglobin (Hb) mutations, including HbS and HbC, can cause sickle cell disease (SCD) when both alleles are inherited (HbSS and HbSC). In SCT, one allele is inherited...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37108709
DOI: 10.3390/ijms24087546
PMCID: PMC10141851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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