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Article

Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus.

The Journal of clinical investigation - 1 Dec 2012

Rodig Scott J, Cheng Jingwei, Wardzala Jacek, DoRosario Andrew, Scanlon Jessica J, Laga Alvaro C, Martinez-Fernandez Alejandro, Barletta Justine A, Bellizzi Andrew M, Sadasivam Subhashini, Holloway Dustin T, Cooper Dylan J, Kupper Thomas S, Wang Linda C, DeCaprio James A

Abstract excerpt

A human polyomavirus was recently discovered in Merkel cell carcinoma (MCC) specimens. The Merkel cell polyomavirus (MCPyV) genome undergoes clonal integration into the host cell chromosomes of MCC tumors and expresses small T antigen and truncated large T antigen. Previous studies have consistently reported that MCPyV can be detected in approximately 80% of all MCC tumors. We sought to increase the sensitivity...

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Share to Antibodies, Viral
Share to Antigens, Polyomavirus Transforming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Merkel Cell

Share to Genes, Tumor Suppressor

Share to Molecular Diagnostic Techniques

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Share to Polyomavirus Infections

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Source

Open in PubMed Open full text

Identifiers

PMID: 23114601
DOI: 10.1172/JCI64116
PMCID: PMC3533549

Genes

MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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