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Article

Hotspot mutations in polyomavirus positive and negative Merkel cell carcinomas.

Cancer genetics - 1 Jan 2000

Veija Tuukka, Sarhadi Virinder Kaur, Koljonen Virve, Bohling Tom, Knuutila Sakari

Abstract excerpt

Merkel cell polyomavirus (MCV) infection underlies most Merkel cell carcinoma (MCC), a primary neuroendocrine carcinoma of the skin. While previous research has focused on MCV-positive MCC tumors, less is known about the oncogenesis in MCV-negative tumors. In this study, we analyzed mutational status of 27 MCC tumors with known MCV status for hotspot regions of 50 cancer-related genes by targeted next-generation...

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Source

Identifiers

PMID: 26725423
DOI: 10.1016/j.cancergen.2015.11.006

Genes

MCC
EGFR
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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