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Article

Does MBL2 codon 54 polymorphism play a role in the pathogenesis of psoriasis?

International journal of dermatology - 1 Jan 2014

Turan Hakan, Karkucak Mutlu, Yakut Tahsin, Ozsahin Mustafa, Gurlevik Zehra, Yanik Mehmet Emin, Ucgun Taner, Aliagaoglu Cihangir, Yaykasli Kursat Oguz

Abstract excerpt

BACKGROUND: Psoriasis is a T cell-mediated immune disease in which various cytokines, primarily tumor necrosis factor-α (TNF-α), are complexly involved. Mannose-binding lectin (MBL) gene polymorphisms decrease MBL serum levels, thereby increasing the synthesis of proinflammatory cytokines such as TNF-α. OBJECTIVES: This trial was designed to evaluate the role of the MBL2 codon 54 polymorphism in the pathogenesis...

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Source

Identifiers

PMID: 23113841
DOI: 10.1111/j.1365-4632.2012.5657.x

Genes

MBL2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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