Article
Matrix Gla protein reinforces angiogenic resolution.
Microvascular research - 1 Jan 2013
Sharma Bikram, Albig Allan R
Abstract excerpt
Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear. Utilizing a mouse MGP knockout model we found that MGP suppresses angiogenic sprouting from mouse aorta restricts microvascular density in cardiac and skeletal muscle, and is an endogenous...
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