Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis.

Blood - 1 Jul 2006

Leung Tinchung, Chen Hui, Stauffer Anna M, Giger Kathryn E, Sinha Soniya, Horstick Eric J, Humbert Jasper E, Hansen Carl A, Robishaw Janet D

Abstract excerpt

Vascular endothelial growth factor (VEGF) is a major mediator of pathologic angiogenesis, a process necessary for the formation of new blood vessels to support tumor growth. Historically, VEGF has been thought to signal via receptor tyrosine kinases, which are not typically considered to be G protein dependent. Here, we show that targeted knockdown of the G protein gng2 gene (Ggamma2) blocks the normal angiogenic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GTP-Binding Protein gamma Subunits
Share to GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Animal

Share to Neovascularization, Physiologic

Share to Phospholipase C gamma

Share to Proto-Oncogene Proteins c-akt

Share to Vascular Endothelial Growth Factor A

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 16537812
DOI: 10.1182/blood-2005-09-3706
PMCID: PMC1895829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis.PMID 16537812Read ↗

G protein subunit alpha i2's pivotal role in angiogenesisSemantic proximity Read ↗

G13 controls angiogenesis through regulation of VEGFR-2 expression.Semantic proximity Read ↗

Capillary Morphogenesis gene 2 mediates multiple pathways of growth factor-induced angiogenesis by regulating endothelial cell chemotaxisSemantic proximity Read ↗

VEGF Receptor Signal TransductionSemantic proximity Read ↗

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.Semantic proximity Read ↗

MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ.Semantic proximity Read ↗

Matrix Gla protein reinforces angiogenic resolution.Semantic proximity Read ↗

Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling.Semantic proximity Read ↗

Vegfd modulates both angiogenesis and lymphangiogenesis during zebrafish embryonic developmentSemantic proximity Read ↗

Syndecan-2 is essential for angiogenic sprouting during zebrafish development.Semantic proximity Read ↗

Metallothionein 2 regulates endothelial cell migration through transcriptional regulation of vegfc expressionSemantic proximity Read ↗

Gestational Loss and Growth Restriction by Angiogenic Defects in Placental Growth Factor Transgenic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.