Article
Angiomodulin is a specific marker of vasculature and regulates vascular endothelial growth factor-A-dependent neoangiogenesis.
Circulation research - 17 Jul 2009
Hooper Andrea T, Shmelkov Sergey V, Gupta Sunny, Milde Till, Bambino Kathryn, Gillen Kelly, Goetz Mollie, Chavala Sai, Baljevic Muhamed, Murphy Andrew J, Valenzuela David M, Gale Nicholas W, Thurston Gavin, Yancopoulos George D, Vahdat Linda, Evans Todd, Rafii Shahin
Abstract excerpt
Blood vessel formation is controlled by the balance between pro- and antiangiogenic pathways. Although much is known about the factors that drive sprouting of neovessels, the factors that stabilize and pattern neovessels are undefined. The expression of angiomodulin (AGM), a vascular endothelial growth factor (VEGF)-A binding protein, was increased in the vasculature of several human tumors as compared to normal...
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