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Article

LRG1 Alters Pericyte Phenotype and Compromises Vascular Maturation

14 Apr 2025

Abstract excerpt

Upregulation of leucine-rich alpha-2-glycoprotein-1 (LRG1) contributes to aberrant neovascularization in many different diseases. In contrast, LRG1 is not involved in developmental angiogenesis. Here, we investigated the vasculopathic properties of LRG1 by examining its effect on developing retinal blood vessels. By injecting recombinant protein or an expression vector into the mouse retina during vascular...

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PMID: 40277918
DOI: 10.3390/cells14080593

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