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Article

Expression of the growth factor progranulin in endothelial cells influences growth and development of blood vessels: a novel mouse model.

PloS one - 1 Jan 2013

Toh Huishi, Cao Mingju, Daniels Eugene, Bateman Andrew

Abstract excerpt

Progranulin is a secreted glycoprotein that regulates cell proliferation, migration and survival. It has roles in development, tumorigenesis, wound healing, neurodegeneration and inflammation. Endothelia in tumors, wounds and placenta express elevated levels of progranulin. In culture, progranulin activates endothelial proliferation and migration. This suggested that progranulin might regulate angiogenesis. It...

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Identifiers

PMID: 23741441
DOI: 10.1371/journal.pone.0064989
PMCID: PMC3669103

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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