Article
KRAS genotyping as biomarker in colorectal cancer: a comparison of three commercial kits on histologic material.
Anticancer research - 1 Dec 2010
Cavallini Aldo, Valentini Anna Maria, Lippolis Catia, Campanella Daniela, Guerra Vito, Caruso Maria Lucia
Abstract excerpt
BACKGROUND/AIM: The crucial role of KRAS status in new colorectal cancer target therapy raises the issue regarding which testing method to use. This study analysed 112 formalin fixed, paraffin-embedded (FFPE) metastatic tissue samples using three different commercially available kits. PATIENTS AND METHODS: A group of 40 KRAS wild-type (wt), 40 codon 12-mutated and 32 codon-13 mutated samples, previously evaluated...
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