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Article

The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN).

Journal of negative results in biomedicine - 25 Dec 2010

Scheckenbach Kathrin, Papadopoulou Galatia, Hoffmann Thomas K, Chaker Adam, Bier Henning, Schipper Jörg, Balz Vera, Wagenmann Martin

Abstract excerpt

BACKGROUND: The checkpointkinase 2 (CHK2) is part of the highly conserved ATM-CHK2 signaling pathway, which is activated in response to DNA damage, in particular after double strand breaks which can be caused by carcinogens like smoking. After induction of downstream targets, e.g. the tumor suppressor p53, its activation leads to cell cycle arrest and apoptosis. Recently, the presence of CHK2 germ line mutations,...

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Source

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Identifiers

PMID: 21184685
DOI: 10.1186/1477-5751-9-10
PMCID: PMC3018459

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The checkpointkinase 2 (CHK2) 1100delC germ line mutation is not associated with the development of squamous cell carcinoma of the head and neck (SCCHN).PMID 21184685Read ↗

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CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population.Semantic proximity Read ↗

Frequency of CHEK2 mutations in a population based, case-control study of breast cancer in young women.Semantic proximity Read ↗

CHEK2*1100delC is not an important high-risk gene in families with hereditary prostate cancer in southern Sweden.Semantic proximity Read ↗

CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia.Semantic proximity Read ↗

The CHEK2 1100delC allele is not relevant for risk assessment in HNPCC and HBCC Spanish families.Semantic proximity Read ↗

Polymorphic hCHK2/hCds1 codon 84 allele and risk of squamous cell carcinoma of the head and neck--a case-control analysis.Semantic proximity Read ↗

Restoration of fragile histidine triad expression restores Chk2 activity in response to ionizing radiation in oral squamous cell carcinoma cells.Semantic proximity Read ↗

Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype.Semantic proximity Read ↗

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Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.Semantic proximity Read ↗

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