Article
Dominant tolerance to kidney allografts induced by anti-donor MHC class II antibodies: cooperation between T and non-T CD103+ cells.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006
Degauque Nicolas, Lair David, Dupont Alexandre, Moreau Anne, Roussey Gwénaelle, Moizant Frédérique, Hubert François Xavier, Louvet Cédric, Hill Marcelo, Haspot Fabienne, Josien Régis, Usal Claire, Vanhove Bernard, Soulillou Jean Paul, Brouard Sophie
Abstract excerpt
Allograft acceptance can be induced in the rat by pretransplant infusion of donor blood or spleen cells. Although promoting long-term acceptance, this treatment is also associated with chronic rejection. In this study, we show that a single administration of anti-donor MHC class II alloimmune serum on the day of transplantation results in indefinite survival of a MHC-mismatched kidney graft. Long-term recipients...
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