Article
Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition.
Oncogene - 18 Aug 1997
Garton A J, Burnham M R, Bouton A H, Tonks N K
Abstract excerpt
The protein tyrosine phosphatase PTP-PEST displays remarkable substrate specificity, in vitro and in vivo for p130cas a signalling intermediate implicated in mitogenic signalling, cell-adhesion induced signalling, and in transformation by a variety of oncogenes. We have identified a high affinity...
Topics
- Animals
- Binding Sites
- COS Cells
- Mutation
- Phosphoproteins
- Phosphorylation
- Proline
- Protein Tyrosine Phosphatase, Non-Receptor Type 12
- Protein Tyrosine Phosphatases
- Proteins
- Retinoblastoma-Like Protein p130
- Signal Transduction
- Substrate Specificity
- src Homology Domains